Here's something interesting. Each actor who voices a Spider-Man has previously voiced the character in a animated series. From wikipedia:
Each Spider-Man is voiced by a different actor who has voiced Spider-Man in the past. Neil Patrick Harris, who voiced Spider-Man in Spider-Man: The New Animated Series, voices the Amazing Spider-Man of the mainstream Marvel universe. Christopher Daniel Barnes, who portrayed Spider-Man in Spider-Man: The Animated Series, voices Spider-Man Noir. Spider-Man 2099 is portrayed by Dan Gilvezan, who was the voice of Spider-Man in Spider-Man and His Amazing Friends. Finally, Ultimate Spider-Man is voiced by Josh Keaton, who lent his voice in the 2008 series, The Spectacular Spider-Man. Stan Lee narrates the story, which Lee has not done in a video game since 2001's Spider-Man 2: Enter Electro.